
Package index
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stress_spec() - Define the pre-specified MMRM to stress-test
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stress_spec_mmrm() - Build a stress spec from a fitted mmrm model
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stress_spec_adam() - Build a stress spec from an ADaM basic data structure
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spec_update() - Modify a stress spec
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stress_fit() - Fit one MMRM and return one row
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stress_covariance() - Perturbation family: within-subject covariance structure
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stress_inference() - Perturbation family: degrees-of-freedom method and variance estimator
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default_inference() - Default inference settings for
stress_inference() -
stress_covariates() - Perturbation family: covariate set
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stress_weights() - Perturbation family: least-squares-mean weighting
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stress_data() - Perturbation family: alternative analysis data sets
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stress_population() - Perturbation family: analysis population
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stress_loo() - Perturbation family: leave-one-out deletions
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stress_grid() - Perturbation family: crossed specification grid
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stress_permute() - Perturbation family: re-randomisation (permutation) test
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stress_tipping() - Perturbation family: delta-adjusted multiple imputation (tipping point)
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stress_reference() - Perturbation family: reference-based multiple imputation
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stress_estimator() - Perturbation family: estimator class
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stress_fragility() - Smallest set of subjects whose removal changes the conclusion
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stress_curve() - Perturbation family: a curve over a continuous data perturbation
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stress_estimand() - Perturbation family: intercurrent-event strategies (ICH E9(R1))
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stress_visits() - Perturbation family: the contrast at every visit
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stress_ranktest() - Perturbation family: rank tests at the contrast visit
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stress_census() - Assemble a census of perturbations against the base analysis
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summary(<stress_census>) - Summarise a census by family
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stress_verdict() - Classify the census: robust, sensitive or fragile, and marginal
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stress_path() - Smallest combination of analytic changes that leaves the confidence interval
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path_changes() - Candidate analytic changes for the path search
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tipping_point() - Find where a p-value curve crosses alpha
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stress_explain() - Explain why an alternative analysis moved
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stress_direction() - Direction stability of a result that misses significance
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stress_plan() - Pre-specify a stress test
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standard_plan() - The standard stress test
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run_plan() - Run a pre-specified stress test
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run_plans() - Run several plans (several endpoints or comparisons) and compare
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stress_report() - Write a stress-test report
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stress_tables() - Write regulatory-style tables and the census
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stress_log() - Write the run log for an audit trail
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stress_html() - Interactive HTML report
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stress_sap() - Statistical-analysis-plan text for a stress test
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mask_ids() - Mask subject identifiers in a census
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plot(<stress_census>) - Plot a census: one row per family on the percent-of-base axis
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plot_swarm() - Swarm of every re-analysis against the filed result
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plot_forest() - Forest plot of the filed analysis and the supplementary rows
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plot_pcurve() - Plot p-value curves over a continuous perturbation
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plot_pstrip() - Strip plot of p-values after each deletion
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plot_pcdf() - Empirical distribution of the p-values across a census
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stress_design()print(<stress_design>) - Size a trial for a robust result
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plot(<stress_design>) - Plot power and robustness power against the sample size
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simulate_trial() - Simulate a two-arm longitudinal trial
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simulate_rare_trial() - Simulate a small trial with rare-disease features
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stress_calibrate() - Pre-trial calibration of the stress test